Non-sequential and multi-step splicing of the dystrophin transcript

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Non-sequential and multi-step splicing of the dystrophin transcript

The dystrophin protein encoding DMD gene is the longest human gene. The 2.2 Mb long human dystrophin transcript takes 16 hours to be transcribed and is co-transcriptionally spliced. It contains long introns (24 over 10kb long, 5 over 100kb long) and the heterogeneity in intron size makes it an ideal transcript to study different aspects of the human splicing process. Splicing is a complex proce...

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ژورنال

عنوان ژورنال: RNA Biology

سال: 2016

ISSN: 1547-6286,1555-8584

DOI: 10.1080/15476286.2015.1125074